Molecular Medicine Genetic Deletion of Chemokine Receptor Ccr6 Decreases Atherogenesis in ApoE-Deficient Mice
نویسندگان
چکیده
Objective: Our objective was to delineate the role of Ccr6 in atherogenesis in the apolipoprotein E–deficient (ApoE / ) mouse model of atherosclerosis. Methods and Results: Both Ccr6 and Ccl20 are expressed in atherosclerotic aorta from ApoE / mice. Aortic lesion area in Ccr6 / ApoE / mice was 40% and 30% smaller than in Ccr6 / ApoE / mice at 16 and 24 weeks of age, respectively. Transplantation of bone marrow from Ccr6 / mice into ApoE / mice resulted in 40% less atherosclerotic lesion area than for bone marrow from Ccr6 / mice; lesions in Ccr6 / ApoE / mice had 44% less macrophage content than lesions in Ccr6 / ApoE / mice. Ccr6 was expressed on a subset of
منابع مشابه
Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice.
RATIONALE The chemokine receptor Ccr6 is a G-protein-coupled receptor expressed on various types of leukocytes identified in mouse atherosclerotic lesions. Recent evidence suggests that both CCR6 and its ligand CCL20 are also present in human atheroma; however, their functional roles in atherogenesis remain undefined. OBJECTIVE Our objective was to delineate the role of Ccr6 in atherogenesis ...
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AIMS Recent evidence suggests that both Ccr7 and its ligands, Ccl19 and Ccl21, are present in mouse and human atherosclerotic plaques; however, the role of Ccr7 in atherogenesis is still controversial. Here, we addressed this question by using the classic apolipoprotein E-deficient (ApoE(-/-)) mouse model of atherosclerosis. METHODS AND RESULTS Ccr7(-/-)ApoE(-/-) double knockout mice and Ccr7...
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